LAVC 5 Human Physiology Hyperthyroidism and Hypothyroidism Discussion

1) You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs).

• Peroxidine: A drug that inhibits thyroid peroxidase from functioning
• Cimigine: A drug that inhibits potassium/iodine cotransporter
• Iodimine: A drug that inhibits iodinase from functioning
• Aldosine: A drug that inhibits production of angiotensinogen from the liver
• Aldoramine: A drug that inhibits sodium/iodine cotransporter
• Thyromine: A drug that stimulates thyroglobulin production                      
• identify the drug(s) that would be successful in treating hyperthyroidism and hypothyroidism, and explain why and how they would be successful.

2) During the early days of neuroscience, neurosurgeons would cut away brain segments to see how it affected the person, which enabled them to learn the function of different brain segments. Assume that the surgeons were trying to learn how respiration worked in this same manner. Which body or brain parts, if removed, would affect respiration (inhalation and exhalation)?

3)Certain villages in India are very conservative and women are required to wear clothes that completely cover their entire body. Unfortunately, these women experience bone pain, fractures, muscle weakness, and depression. Explain the relationship between their attire and the signs and symptoms they are experiencing?

4) Marie Curie was a famous French-Polish scientist known for her pioneering research on radioactivity. Her work not only brought her fame but her death as well; she developed aplastic anemia due to radiation exposure. She experienced recurrent and prolonged infections (viral, bacterial, parasitic, and fungal). Explain why she suffered from recurrent infections. Be sure to mention the different types of WBC and the relation to the various infections, and the reasons why she lacked the cell-mediated and the humeral response.

5) Apart from suffering from recurrent and prolonged infections, Marie Curie also experienced the following signs and symptoms: fatigue, rapid heart rate, pale skin, easy bruising, prolonged bleeding from cuts, and dizziness. Bone marrow transplant was not an option at that time and so blood transfusion was the treatment of choice. Explain the reasoning behind these other signs and symptoms that Curie experienced. Assume her blood group was A negative. Which blood groups can she receive? Which blood groups can she not receive? Explain why